Rewiring of hindlimb corticospinal neurons after spinal cord injury

Abstract

Little is known about the functional role of axotomized cortical neurons that survive spinal cord injury. Large thoracic spinal cord injuries in adult rats result in impairments of hindlimb function. Using retrograde tracers, we found that axotomized corticospinal axons from the hindlimb sensorimotor cortex sprouted in the cervical spinal cord. Mapping of… (More)
DOI: 10.1038/nn.2448

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