Rewiring of genetic networks in response to DNA damage.

  title={Rewiring of genetic networks in response to DNA damage.},
  author={Sourav Bandyopadhyay and Monika Mehta and Dwight Kuo and Min-Kyung Sung and Ryan Chuang and Eric J. Jaehnig and Bernd Bodenmiller and Katherine Licon and Wilbert B. Copeland and Michael Shales and Dorothea Fiedler and Janusz Dutkowski and Aude Gu{\'e}nol{\'e} and Haico van Attikum and Kevan M. Shokat and Richard D Kolodner and Won-Ki Huh and Ruedi Aebersold and M K Keogh and Nevan J. Krogan and Trey Ideker},
  volume={330 6009},
Although cellular behaviors are dynamic, the networks that govern these behaviors have been mapped primarily as static snapshots. Using an approach called differential epistasis mapping, we have discovered widespread changes in genetic interaction among yeast kinases, phosphatases, and transcription factors as the cell responds to DNA damage. Differential interactions uncover many gene functions that go undetected in static conditions. They are very effective at identifying DNA repair pathways… CONTINUE READING
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