Rewiring kinase specificity with a synthetic adaptor protein.

  title={Rewiring kinase specificity with a synthetic adaptor protein.},
  author={Elissa M Hobert and Alanna Schepartz},
  journal={Journal of the American Chemical Society},
  volume={134 9},
Signaling cascades are managed in time and space by interactions between and among proteins. These interactions are often aided by adaptor proteins, which guide enzyme-substrate pairs into proximity. Miniature proteins are a class of small, well-folded protein domains possessing engineered binding properties. Here we made use of two miniature proteins with… CONTINUE READING