Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors

@article{Yeh2007RewiringCM,
  title={Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors},
  author={Brian J. Yeh and Robert J. Rutigliano and Anrica Deb and Dafna Bar-Sagi and Wendell A Lim},
  journal={Nature},
  year={2007},
  volume={447},
  pages={596-600}
}
Eukaryotic cells mobilize the actin cytoskeleton to generate a remarkable diversity of morphological behaviours, including motility, phagocytosis and cytokinesis. Much of this diversity is mediated by guanine nucleotide exchange factors (GEFs) that activate Rho family GTPases—the master regulators of the actin cytoskeleton. There are over 80 Rho GEFs in the human genome (compared to only 22 genes for the Rho GTPases themselves), and the evolution of new and diverse GEFs is thought to provide a… CONTINUE READING