Rewiring and dosing of systems modules as a design approach for synthetic mammalian signaling networks.

@article{Kmpf2012RewiringAD,
  title={Rewiring and dosing of systems modules as a design approach for synthetic mammalian signaling networks.},
  author={Michael M. K{\"a}mpf and R. Engesser and Moritz Busacker and Maximilian H{\"o}rner and Maria Karlsson and Matias D. Zurbriggen and Martin Fussenegger and Jens Timmer and Wilfried Weber},
  journal={Molecular bioSystems},
  year={2012},
  volume={8 6},
  pages={1824-32}
}
Modularly structured signaling networks coordinate the fate and function of complex biological systems. Each component in the network performs a discrete computational operation, but when connected to each other intricate functionality emerges. Here we study such an architecture by connecting auxin signaling modules and inducible protein biotinylation systems with transcriptional control systems to construct synthetic mammalian high-detect, low-detect and band-detect networks that translate… CONTINUE READING
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