Rewinding the DISC

  title={Rewinding the DISC},
  author={Benjamin Chaigne-Delalande and J. -F. Moreau and Patrick Legembre},
  journal={Archivum Immunologiae et Therapiae Experimentalis},
Fas (CD95/APO-1) belongs to the tumor necrosis factor receptor family and its signaling pathway has been extensively studied over the past 15 years. Blockade of the Fas-mediated apoptotic signal leads to abusive lymphoproliferation, auto-immunity, and an increased risk of developing lymphoma and leukemia. Fas engagement drives the formation of a complex termed DISC (death-inducing signaling complex), which contains the adaptor molecule Fas-associated protein, two members of the caspase family… CONTINUE READING


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