• Corpus ID: 22567883

Rewarding properties of some drugs studied by place preference conditioning.

  title={Rewarding properties of some drugs studied by place preference conditioning.},
  author={Grazyna Biala and R. Langwiński},
  journal={Polish journal of pharmacology},
  volume={48 4},
Ethanol, morphine, cocaine and amphetamine were examined in place conditioning. After determination of initial preferences, animals were conditioned with ethanol (1 g/kg), morphine (5 mg/kg), cocaine (5 mg/kg) and amphetamine (5 mg/kg) alone or with combinations of these drugs plus naloxone (1 mg/kg). Naloxone prevented the ability of all drugs used to produce a place preference. The reinforcing properties of ethanol and morphine were reduced by sodium nitroprusside at a dose equal to 1/10 of… 
Acquisition and expression of ethanol-induced conditioned place preference in mice is inhibited by naloxone.
  • M. Wróbel
  • Psychology, Medicine
    Pharmacological reports : PR
  • 2011
It is suggested that an unbiased version of ethanol-induced CPP in C57BL/6 mice could be a valid model for the study of the motivational effects of ethanol, confirming and expanding previous findings that have demonstrated inhibitory effects of opioid receptor antagonist on alcohol conditioned reward.
Ethanol consumption and reward are decreased in µ-opiate receptor knockout mice
Heterozygous and homozygous MOR KO mice consumed less ethanol than wild-type mice, and females, especially females, exhibited less ethanol reward in a conditioned place preference paradigm, fitting with the reported therapeutic efficacy of MOR antagonists in the treatment of human alcoholism.
Nitric oxide mediation of morphine-induced place preference in the nucleus accumbens of rat.
The results indicate that NO may be involved in the acquisition and expression of morphine-induced place preference and that already established morphine- induced place preference was inhibited by L-NAME.
Involvements of stress hormones in the restraint-induced conditioned place preference
It is concluded that CRFR1 plays an essential role in the neural mechanism of restraint-induced CPP, and negative feedback of CORT from peripheral sources may not be involved in this phenomenon.
Influence of nitric oxide on morphine-induced amnesia and interactions with dopaminergic receptor agents
It is concluded that the morphine-induced impairment of memory formation can be prevented by nitric oxide donor and, in this effect, dopaminergic mechanism is involved.
NMDA or AMPA/kainate receptor blockade prevents acquisition of conditioned place preference induced by D2/3 dopamine receptor stimulation in rats
Acquisition of place conditioning induced by systemic administration of 7-OH-DPAT is blocked by systemic NMDA receptor antagonism by MK-801 or by the AMPA/kainate receptor antagonist NBQX microinjected into the NAS shell subregion.
Effects of nitric oxide on morphine self-administration in rat
No may have a role in morphine self-administration through the release of nitric oxide through the effects of acute and chronic administration of the NO precursor, L-arginine and NO synthase (NOS) inhibitor,L-nitro-amino-methyl-ester (L-NAME).
Nitric oxide within the ventral tegmental area is involved in mediating morphine reward.
The results indicate that NO may be involved in the acquisition and expression of morphine-induced place preference and suggest that N(G)-nitro-L-arginine methyl ester may also be involved.
Sulpiride injections into the medial septum reverse the influence of intra-medial septum injection of l-arginine on expression of place conditioning-induced by morphine in rats
It can be concluded that L-arginine, a precursor of nitric oxide, in the rat median septum may play a role in expression of morphine conditioning due to dopamine release in this area.
Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues
It is clear that during the past decade place preference conditioning has become a valuable and firmly established and very widely used tool in behavioural pharmacology and addiction research.