Reward or its denial during the neonatal period affects adult spatial memory and hippocampal phosphorylated cAMP response element-binding protein levels of both the neonatal and adult rat.

@article{Diamantopoulou2011RewardOI,
  title={Reward or its denial during the neonatal period affects adult spatial memory and hippocampal phosphorylated cAMP response element-binding protein levels of both the neonatal and adult rat.},
  author={Anastasia Diamantopoulou and Antonios Stamatakis and Theofanis Panagiotaropoulos and Fotini Stylianopoulou},
  journal={Neuroscience},
  year={2011},
  volume={181},
  pages={89-99}
}
Early life experiences, particularly mother-infant interactions, have been shown to influence adult coping and learning abilities via gene-environment interactions. We have developed a paradigm, in which mother contact is used as either a positive or a negative reinforcer in a T-maze, during postnatal days 10-13. In both neonates receiving (RER) or denied (DER) the expected reward, exposure to the memory test in the absence of the mother resulted in a remarkable increase in the number of pCREB… CONTINUE READING