Reward and Social Valuation Deficits following Ventromedial Prefrontal Damage
@article{Moretti2009RewardAS, title={Reward and Social Valuation Deficits following Ventromedial Prefrontal Damage}, author={Laura Moretti and Davide Dragone and Giuseppe Di Pellegrino}, journal={Journal of Cognitive Neuroscience}, year={2009}, volume={21}, pages={128-140} }
Lesion and imaging studies have implicated the ventromedial prefrontal cortex (vmPFC) in economic decisions and social interactions, yet its exact functions remain unclear. Here, we investigated the hypothesis that the vmPFC represents the subjective value or desirability of future outcomes during social decision-making. Both vmPFC-damaged patients and control participants acted as the responder in a single-round ultimatum game. To test outcome valuation, we contrasted concrete, immediately…
103 Citations
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References
SHOWING 1-10 OF 85 REFERENCES
Choosing between Small, Likely Rewards and Large, Unlikely Rewards Activates Inferior and Orbital Prefrontal Cortex
- Biology, PsychologyThe Journal of Neuroscience
- 1999
The results suggest that decision making recruits neural activity from multiple regions of the inferior PFC that receive information from a diverse set of cortical and limbic inputs, and that the contribution of the orbitofrontal regions may involve processing changes in reward-related information.
The role of ventromedial prefrontal cortex in decision making: judgment under uncertainty or judgment per se?
- PsychologyCerebral cortex
- 2007
Ventromedial prefrontal cortex (VMF) is thought to be important in human decision making, but studies to date have focused on decision making under conditions of uncertainty, including risky or…
Irrational Economic Decision-Making after Ventromedial Prefrontal Damage: Evidence from the Ultimatum Game
- PsychologyThe Journal of Neuroscience
- 2007
Results suggest that emotion regulation processes subserved by VMPC are a critical component of normal economic decision making, and damage to ventromedial prefrontal cortex (VMPC), an area critical for the modulation of emotional reactions, would result in exaggerated irrational economic decisions.
Dissociable Contributions of the Human Amygdala and Orbitofrontal Cortex to Incentive Motivation and Goal Selection
- Psychology, BiologyThe Journal of Neuroscience
- 2003
The present study examined the neural substrates by which appetitive incentive value influences prospective goal selection, using positron emission tomographic neuroimaging in humans to highlight the differential contribution of the amygdala and regions within the orbitof cortex in a neural system underlying the selection of goals based on the prospective incentive value of stimuli.
Do psychopathic patients use their DLPFC when making decisions in moral dilemmas?
- PsychologyMolecular Psychiatry
- 2009
If the DLPFC was less activated than in healthy individuals, this could suggest that its activity in such a context might only be a by-product of a process of ‘cognitive control’, which would not support the hypothesis that the D LPFC is specifically involved in a subsystem of moral decision making as generally reported in the literature on decision neuroscience.
Reward-related Reversal Learning after Surgical Excisions in Orbito-frontal or Dorsolateral Prefrontal Cortex in Humans
- Psychology, BiologyJournal of Cognitive Neuroscience
- 2004
The results show that the orbital prefrontal cortex is required bilaterally for monitoring changes in the reward value of stimuli and using this to guide behavior in the task; whereas the dorsolateral prefrontal cortex, if it produces deficits in thetask, does so for reasons related to executive functions, such as the control of attention.
Damage to the prefrontal cortex increases utilitarian moral judgements
- PsychologyNature
- 2007
It is shown that six patients with focal bilateral damage to the ventromedial prefrontal cortex (VMPC), a brain region necessary for the normal generation of emotions, produce an abnormally ‘utilitarian’ pattern of judgements on moral dilemmas that pit compelling considerations of aggregate welfare against highly emotionally aversive behaviours.
Acquired Personality Disturbances Associated With Bilateral Damage to the Ventromedial Prefrontal Region
- PsychologyDevelopmental neuropsychology
- 2000
Differences between this syndrome of "acquired sociopathy" and developmental psychopathy in characteristic personality disturbances and psychophysiological abnormalities suggest that diminished emotionality, impaired decision making, and psychosocial dysfunction may be related to ventromedial prefrontal dysfunction in both groups.
Characterization of Empathy Deficits following Prefrontal Brain Damage: The Role of the Right Ventromedial Prefrontal Cortex
- Psychology, BiologyJournal of Cognitive Neuroscience
- 2003
The findings suggest that prefrontal structures play an important part in a network mediating the empathic response and specifically that the right ventromedial cortex has a unique role in integrating cognition and affect to produce the empathy response.
Economic decision-making in psychopathy: A comparison with ventromedial prefrontal lesion patients
- PsychologyNeuropsychologia
- 2010