Reward and Aversion.
@article{Hu2016RewardAA, title={Reward and Aversion.}, author={Hailan Hu}, journal={Annual review of neuroscience}, year={2016}, volume={39}, pages={ 297-324 } }
To benefit from opportunities and cope with challenges in the environment, animals must adapt their behavior to acquire rewards and to avoid punishments. Maladaptive changes in the neuromodulatory systems and neural circuits for reward and aversion can lead to manifestation of several prominent psychiatric disorders including addiction and depression. Recent progress is pushing the boundaries of knowledge on two major fronts in research on reward and aversion: First, new layers of complexity…
183 Citations
Cell-type and projection-specific dopaminergic encoding of aversive stimuli in addiction
- Psychology, BiologyBrain Research
- 2019
How Reward and Aversion Shape Motivation and Decision Making: A Computational Account
- Psychology, BiologyThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
- 2019
This review considers substance addiction and overeating as states of altered value-based decision making, in which the expectation of reward chronically outweighs the costs associated with substance use and food consumption, respectively.
Reward-centricity and attenuated aversions: An adolescent phenotype emerging from studies in laboratory animals
- Psychology, BiologyNeuroscience & Biobehavioral Reviews
- 2016
An Update on the Role of Serotonin and its Interplay with Dopamine for Reward
- Biology, PsychologyFront. Hum. Neurosci.
- 2017
It appears that the additive effect of serotonin and DA conveys significant reward related information and is subjectively highly euphorizing, and this pattern of results indicates that joint activity between both systems carries essential reward information and invites parallel investigation of both neurotransmitter systems.
A mathematical model of reward-mediated learning in drug addiction.
- Psychology, BiologyChaos
- 2022
A simple and easily interpretable dynamical systems model to describe the neurobiology of drug addiction that incorporates the psychiatric concepts of reward prediction error, drug-induced incentive salience, and opponent process theory is proposed.
Bidirectional regulation of reward, punishment, and arousal by dopamine, the lateral habenula and the rostromedial tegmentum (RMTg)
- Psychology, BiologyCurrent Opinion in Behavioral Sciences
- 2019
The Aversion Function of the Limbic Dopaminergic Neurons and Their Roles in Functional Neurological Disorders
- Psychology, BiologyFrontiers in Cell and Developmental Biology
- 2021
The recent advances on studies about DAergic neurons involved in aversive stimulus processing at internal conflicts are reviewed and several neural pathways, including four limbic system brain regions, which are involved in the processing of aversion are summarized.
Viral vector strategies for investigating midbrain dopamine circuits underlying motivated behaviors
- Biology, PsychologyPharmacology Biochemistry and Behavior
- 2018
VTA GABA Neurons at the Interface of Stress and Reward
- Biology, PsychologyFront. Neural Circuits
- 2019
The circuit architecture, physiology, and behavioral roles of VTA GABA neurons are dissected and critical gaps to be addressed are suggested to help address addiction, depression, and other stress-linked disorders.
Exploring The Role Of Dopamine Circuits In Eating Behavior
- Psychology, Biology
- 2017
A novel technique is used using a novel technique to accomplish cell-type-specific assessment of neural activity during feeding behavior in the nucleus accumbens as an important regulator of motivation and reward seeking.
References
SHOWING 1-10 OF 245 REFERENCES
Serotonergic modulation of reward and punishment: Evidence from pharmacological fMRI studies
- Psychology, BiologyBrain Research
- 2014
Reward processing by the lateral habenula in normal and depressive behaviors
- Biology, PsychologyNature Neuroscience
- 2014
In insights gained from neuronal recordings in monkeys regarding how the lateral habenula processes reward-related information are discussed, recent optogenetic experiments in rodents addressing normal and abnormal functions of the habenulas are highlighted, and how deregulation is involved in depressive behaviors are discussed.
Dopamine Prediction Errors in Reward Learning and Addiction: From Theory to Neural Circuitry
- Biology, PsychologyNeuron
- 2015
Neuron-type specific signals for reward and punishment in the ventral tegmental area
- Biology, PsychologyNature
- 2012
VTA GABAergic neurons signal expected reward, a key variable for dopaminergic neurons to calculate reward prediction error, and are ‘tagged’ and identified based on their responses to optical stimulation while recording.
Reward processing by the dorsal raphe nucleus: 5-HT and beyond
- Biology, PsychologyLearning & memory
- 2015
Studies so far demonstrate the strong power of DRN neurons in reward signaling and at the same time invite additional efforts to dissect the roles and mechanisms of different DRN neuron types in various processes of reward-related behaviors.
Input-specific control of reward and aversion in the ventral tegmental area
- Biology, PsychologyNature
- 2012
It is established that distinct VTA circuits generate reward and aversion, and thereby provides a new framework for understanding the circuit basis of adaptive and pathological motivated behaviours.
Biological substrates of reward and aversion: A nucleus accumbens activity hypothesis
- Biology, PsychologyNeuropharmacology
- 2009
Dopamine signals for reward value and risk: basic and recent data
- Psychology, BiologyBehavioral and Brain Functions
- 2010
Neurophysiological studies reveal phasic dopamine signals that transmit information related predominantly but not exclusively to reward, which is more restricted and stereotyped than neuronal activity in most other brain structures involved in goal directed behavior.
Dopamine in Motivational Control: Rewarding, Aversive, and Alerting
- Biology, PsychologyNeuron
- 2010