Reward Processing in Unipolar and Bipolar Depression: A Functional MRI Study

  title={Reward Processing in Unipolar and Bipolar Depression: A Functional MRI Study},
  author={Ronny Redlich and Katharina Dohm and Dominik Grotegerd and Nils Opel and Pienie Zwitserlood and Walter Heindel and Volker Arolt and Harald Kugel and Udo Dannlowski},
Differentiating bipolar disorders (BD) from unipolar depression (UD) remains a major clinical challenge. The identification of neurobiological markers may help to differentiate these disorders, particularly during depressive episodes. This cross-sectional study, including 33 patients with UD, 33 patients with BD, and 34 healthy controls, is one of the first to directly compare UD and BD with respect to reward processing. A card-guessing paradigm was employed and brain activity associated with… CONTINUE READING
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