Reviving the Dead: History and Reactivation of an Extinct L1

@inproceedings{Yang2014RevivingTD,
  title={Reviving the Dead: History and Reactivation of an Extinct L1},
  author={Lei Yang and John Brunsfeld and L A Scott and Holly A. Wichman},
  booktitle={PLoS genetics},
  year={2014}
}
Although L1 sequences are present in the genomes of all placental mammals and marsupials examined to date, their activity was lost in the megabat family, Pteropodidae, ∼24 million years ago. To examine the characteristics of L1s prior to their extinction, we analyzed the evolutionary history of L1s in the genome of a megabat, Pteropus vampyrus, and found a pattern of periodic L1 expansion and quiescence. In contrast to the well-characterized L1s in human and mouse, megabat genomes have… CONTINUE READING
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