Revisiting the value of competition assays in folate receptor-mediated drug delivery.

@article{Jones2017RevisitingTV,
  title={Revisiting the value of competition assays in folate receptor-mediated drug delivery.},
  author={Steven K. Jones and Anwesha Sarkar and Daniel Paul Feldmann and Peter Manfred Hoffmann and Olivia M Merkel},
  journal={Biomaterials},
  year={2017},
  volume={138},
  pages={
          35-45
        }
}
Polymeric nanoparticles have been studied for gene and drug delivery. These nanoparticles can be modified to utilize a targeted delivery approach to selectively deliver their payload to specific cells, while avoiding unwanted delivery to healthy cells. One commonly over-expressed receptor which can be targeted by ligand-conjugated nanoparticles is the folate receptor alpha (FRα). The ability to target FRα remains a promising concept, and therefore, understanding the binding dynamics of the… CONTINUE READING
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