Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy.

@article{Newton2015RevisitingTS,
  title={Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy.},
  author={Jason C Newton and Santiago Lima and Michael W Maceyka and Sarah E. Spiegel},
  journal={Experimental cell research},
  year={2015},
  volume={333 2},
  pages={
          195-200
        }
}
Nearly two decades have passed since it was first proposed that regulation of the interconvertible sphingolipid metabolites, ceramide and sphingosine-1-phosphate (S1P), and their opposing signaling pathways are major determinants of cell fate, a concept referred to as the “sphingolipid rheostat”. Since then, many reports have substantiated the role of the sphingolipid rheostat in cell fate determination and in the initiation, progression, and drug sensitivity of cancer. Thus, modulation of the… CONTINUE READING

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