Revisiting the scissor-like mechanism of activation for the erythropoietin receptor.

Abstract

An interpretation of alternative crystal structures of the erythropoietin receptor, with and without ligand, led to the proposal of a scissor-like mechanism of activation. This model has been propagated in the literature and is still being used to interpret crystal structures of related type-I cytokine receptors. Here, we assess whether the model remains compatible with current knowledge on the family of type-I cytokine receptors, and consider whether the model, as initially presented, is truly supported by the crystal structures on which it was originally based.

DOI: 10.1002/1873-3468.12340

Cite this paper

@article{Corbett2016RevisitingTS, title={Revisiting the scissor-like mechanism of activation for the erythropoietin receptor.}, author={Michael S P Corbett and David Poger and Alan E. Mark}, journal={FEBS letters}, year={2016}, volume={590 18}, pages={3083-8} }