Revisiting the regulated secretory pathway: from frogs to human.

  title={Revisiting the regulated secretory pathway: from frogs to human.},
  author={Rafael V{\'a}zquez-Mart{\'i}nez and Alberto D{\'i}az-Ru{\'i}z and Farid Almabouada and Yoana Rabanal-Ruiz and Francisco Gracia-Navarro and Mar{\'i}a Del Mar Malag{\'o}n},
  journal={General and comparative endocrinology},
  volume={175 1},
The regulated secretory pathway is a hallmark of endocrine and neuroendocrine cells. This process comprises different sequential steps, including ER-associated protein synthesis, ER-to-Golgi protein transport, Golgi-associated posttranslational modification, sorting and packing of secretory proteins into carrier granules, cytoskeleton-based granule transport towards the plasma membrane and tethering, docking and fusion of granules with specialized releasing zones in the plasma membrane. Each… CONTINUE READING