Revisiting the reactivity of oximate alpha-nucleophiles with electrophilic phosphorus centers. Relevance to detoxification of sarin, soman and DFP under mild conditions.

@article{Terrier2006RevisitingTR,
  title={Revisiting the reactivity of oximate alpha-nucleophiles with electrophilic phosphorus centers. Relevance to detoxification of sarin, soman and DFP under mild conditions.},
  author={F. Terrier and P. Rodr{\'i}guez-Dafonte and E. Le Gu{\'e}vel and G. Moutiers},
  journal={Organic & biomolecular chemistry},
  year={2006},
  volume={4 23},
  pages={
          4352-63
        }
}
  • F. Terrier, P. Rodríguez-Dafonte, +1 author G. Moutiers
  • Published 2006
  • Chemistry, Medicine
  • Organic & biomolecular chemistry
  • Following a potentiometric determination of the relevant pKa values of the (R1R2)C=NOH functionality, the second order rate constants (k(Ox)) for reaction of a large set of oximate bases with two model organophosphorus esters, i.e. bis-(4-nitrophenyl)phenylphosphonate (BNPPP) and bis-(4-nitrophenyl)methylphosphonate (BNPMP), and three toxic compounds, i.e., sarin (GB), soman (GD) and diisopropylphosphorofluoridate (DFP), in aqueous as well as a 30 : 70 (v/v) H2O-Me2SO mixture have been measured… CONTINUE READING
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