Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock

@inproceedings{Taccone2010RevisitingTL,
  title={Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock},
  author={Fabio Silvio Taccone and Pierre F. Laterre and Herbert D. Spapen and Thierry L Dugernier and Isabelle Karine Delattre and Brice Layeux and Daniel De Backer and Xavier Wittebole and Pierre E Wallemacq and Jean-Louis Vincent and Fr{\'e}d{\'e}rique Jacobs},
  booktitle={Critical care},
  year={2010}
}
INTRODUCTION It has been proposed that doses of amikacin of >15 mg/kg should be used in conditions associated with an increased volume of distribution (Vd), such as severe sepsis and septic shock. The primary aim of this study was to determine whether 25 mg/kg (total body weight) of amikacin is an adequate loading dose for these patients. METHODS This was an open, prospective, multicenter study in four Belgian intensive care units (ICUs). All consecutive patients with a diagnosis of severe… CONTINUE READING
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