Revisiting the definition of somatic mutational status in B-cell tumors: does 98% homology mean that a VH-gene is unmutated?

@article{Forconi2004RevisitingTD,
  title={Revisiting the definition of somatic mutational status in B-cell tumors: does 98% homology mean that a VH-gene is unmutated?},
  author={Francesco Forconi and Surinder Singh Sahota and Francesco Nicola Lauria and Freda K Stevenson},
  journal={Leukemia},
  year={2004},
  volume={18},
  pages={882-883}
}
In B-cell tumors, accurate assessment of somatic mutational status has implications for defining tumor origin and, in some categories, has relevance for predicting the clinical outcome. In 1999, it was found that in chronic lymphocytic leukemia (CLL) cases carrying VH-genes with 498% homology to the closest germline (GL) gene identified a subset with a… CONTINUE READING