Revisiting the controversial role of salsolinol in the neurobiological effects of ethanol: old and new vistas.

@article{Hiplito2012RevisitingTC,
  title={Revisiting the controversial role of salsolinol in the neurobiological effects of ethanol: old and new vistas.},
  author={Luc{\'i}a Hip{\'o}lito and Mar{\'i}a Jos{\'e} S{\'a}nchez-Catal{\'a}n and Luc{\'i}a Mart{\'i}-Prats and Luis Granero and Ana Polache},
  journal={Neuroscience and biobehavioral reviews},
  year={2012},
  volume={36 1},
  pages={362-78}
}
The possible involvement of salsolinol (Sal), an endogenous condensation product of ACD (the first metabolite of ethanol) and dopamine, in the neurochemical basis underlying ethanol action has been repeatedly suggested although it has not been unequivocally established, still being a controversial matter of debate. The main goal of this review is to evaluate the presumed contribution of Sal to ethanol effects summarizing the reported data since the discovery in the 1970s of Sal formation in… CONTINUE READING