Revisiting the blood-brain barrier: A hard nut to crack in the transportation of drug molecules

@article{Harilal2020RevisitingTB,
  title={Revisiting the blood-brain barrier: A hard nut to crack in the transportation of drug molecules},
  author={Seetha Harilal and Jobin Jose and Della Grace Thomas Parambi and Rajesh Kumar and Bijo Mathew},
  journal={Brain Research Bulletin},
  year={2020},
  volume={160},
  pages={121-140}
}
Barriers are the hallmark of a healthy physiology, BBB being a tough nut to crack for most of the antigens and chemical substances. The presence of tight junctions plays a remarkable role in defending the brain from antigenic and pathogenic attacks. BBB constitutes a diverse assemblage of multiple physical and chemical barriers that judiciously restrict the flux of blood solutes into and out of the brain. Restrictions through the paracellular pathway and the tight junctions between… 
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