Revisiting the biological roles of PAI2 (SERPINB2) in cancer

@article{Croucher2008RevisitingTB,
  title={Revisiting the biological roles of PAI2 (SERPINB2) in cancer},
  author={David R. Croucher and Darren N Saunders and Sergei Lobov and Marie Ranson},
  journal={Nature Reviews Cancer},
  year={2008},
  volume={8},
  pages={535-545}
}
Tumour expression of the urokinase plasminogen activator correlates with invasive capacity. Consequently, inhibition of this serine protease by physiological inhibitors should decrease invasion and metastasis. However, of the two main urokinase inhibitors, high tumour levels of the type 1 inhibitor actually promote tumour progression, whereas high levels of the type 2 inhibitor decrease tumour growth and metastasis. We propose that the basis of this apparently paradoxical action of two similar… CONTINUE READING
BETA

Tables and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 75 CITATIONS

Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis.

  • Toxicological sciences : an official journal of the Society of Toxicology
  • 2016
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

SERPINB2 down-regulation contributes to chemoresistance in head and neck cancer.

  • Molecular carcinogenesis
  • 2014
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2009
2019

CITATION STATISTICS

  • 13 Highly Influenced Citations

  • Averaged 7 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 158 REFERENCES

American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer

L Harris
  • J Clin Oncol
  • 2007

Control of matrix metalloproteinase catalytic activity.

  • Matrix biology : journal of the International Society for Matrix Biology
  • 2007

High expression of plasminogen activator inhibitor-2 (PAI-2) is a predictor of improved survival in patients with pancreatic adenocarcinoma

R Smith
  • World J Surg 31,
  • 2007

Multiple roles of the candidate oncogene ZNF217 in ovarian epithelial neoplastic progression

P Li
  • Int J Cancer 120,
  • 2007

Preclinical evaluation of 213Bi-labeled plasminogen activator inhibitor type 2 in an orthotopic murine xenogenic model of human breast carcinoma

Stutchbury, T.K
  • Mol Cancer Ther
  • 2007

Similar Papers

Loading similar papers…