Revisiting the arthritogenic peptide theory: quantitative not qualitative changes in the peptide repertoire of HLA-B27 allotypes.

@article{Schittenhelm2015RevisitingTA,
  title={Revisiting the arthritogenic peptide theory: quantitative not qualitative changes in the peptide repertoire of HLA-B27 allotypes.},
  author={Ralf B. Schittenhelm and Terry C C Lim Kam Sian and Pascal G. Wilmann and Nadine L. Dudek and Anthony W. Purcell},
  journal={Arthritis & rheumatology},
  year={2015},
  volume={67 3},
  pages={702-13}
}
OBJECTIVE The association of HLA-B27 with spondyloarthropathy is one of the strongest documented for any autoimmune disease. A common hypothesis for this association is the arthritogenic peptide concept. This dictates that differences in the peptide binding preferences of disease-associated and non-disease-associated HLA-B27 allotypes underlie the presentation of bacterial and self-peptides, leading to cross-reactive T cell immunity and subsequent autoimmune attack of affected tissues. The aim… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

HLA-B27 Anterior Uveitis: Immunology and Immunopathology.

Ocular immunology and inflammation • 2016
View 3 Excerpts
Highly Influenced

HLA Typing

Methods in Molecular Biology • 2018

Similar Papers

Loading similar papers…