Revisiting the Syndrome of “Obsessional Slowness”

  title={Revisiting the Syndrome of “Obsessional Slowness”},
  author={Christos Ganos and Panagiotis Kassavetis and Mar{\'i}a Pilar Sanchis Cerd{\'a}n and Roberto Erro and Bettina Balint and Gary Price and Mark J. Edwards and Kailash P. Bhatia},
  journal={Movement Disorders Clinical Practice},
Obsessional slowness (OS) denotes a rare condition of disablingly slow motor performance. It was originally described in patients with obsessive‐compulsive disorder as a “primary” condition; however, subsequent reports have included heterogeneous clinical populations. We wished to reassess patients with this diagnosis at our own institution and also revisit the literature to provide an overview of this condition. 

Primary Obsessive Slowness: A Complex Presentation and Treatment Difficulties

A case of an 18-year-old male patient who presented debilitating slowness and severe impairment was described and was ultimately improved with escitalopram 30 mg/day combined with memantine 10 mg/ day and amisulpride 400mg/day.

Obsessional slowness in obsessive-compulsive disorder: identifying characteristics and comorbidities in a clinical sample.

This was the first large-scale descriptive study of obsessional slowness, that provided preliminary evidence for an OS phenotype within obsessive-compulsive disorder and also provides preliminary evidence that OS may be a more severe form of OCD.

Catatonia in pediatric obsessive–compulsive disorder: report of two cases

Most cases of catatonia in this small series seemed to have responded to the optimization of the treatment for OCD, highlighting the clinical importance of an accurate diagnosis of cat atonia when associated with OCD.

Emerging concepts on bradykinesia in non‐parkinsonian conditions

Clinical and experimental studies indicate that bradykinesia may also be observed in various neurological diseases not primarily characterized by parkinsonism, including those characterized by the involvement of the cerebellum and corticospinal system, dementia, multiple sclerosis, and psychiatric disorders.

Nosological Dilemma and Clinical Polymorphism of the Catatonia Phenomenon

Catatonia, traditionally treated as a symptom of schizophrenia, currently is predominantly interpreted as a “transnosological syndrome”, which accompanies various (both mental and somatic) diseases.

Use of Electroconvulsive Therapy in Autism.

Use of Electroconvulsive Therapy in Autism.

Association of insight, avoidance behavior, indecisiveness, and inflated responsibility with other clinical characteristics in children and adolescents with obsessive-compulsive disorder

Ancillary dimensions are more a feature of illness severity than differentially associated with individual symptom dimensions in childhood OCD, and Insight and avoidance should be considered for inclusion in the assessment of illnesses severity in childhood obsessive-compulsive disorder.



Obsessive Slowness : A Case Report

A case of a 21 year old male patient who presented with debilitating slowness is described, who responded to a combination of behaviour therapy (thought habituation and exposure) and pharmacotherapy (fluoxetine and thyroxine).

Classification and Treatment of Obsessional Slowness

  • D. Veale
  • Psychology, Medicine
    British Journal of Psychiatry
  • 1993
It is argued that primary obsessional slowness does not require classification as a separate syndrome because it can be found to be secondary to recognised phenomena of obsessive-compulsive disorder or anankastic personality disorder.

Early Onset Obsessive Compulsive Disorder with Obsessive Slowness: A Case Report and Demonstration of Management

A case of early onset severe OCD with obsessive slowness which showed good response to combined pharmacotherapy and behavioral therapy is reported.

Primary obsessional slowness.

  • S. Rachman
  • Psychology, Medicine
    Behaviour research and therapy
  • 1974

The neurology of obsessional slowness.

Patients with obsessional slowness may have a dysfunction in the frontal-basal-ganglia loop system, which is related to the degree of obsessionality or the severity of motor dysfunction.

Obsessional slowness in Down's syndrome.

The case series might serve to establish the need for further, more systematic, prospective evaluation of individuals with DS and clinically significant slowness, which appears to occur infrequently but may be a severe variant of OCD.

Primary obsessional slowness: long-term findings.

Obsessional slowness: a meticulous replication.

Obsessional slowness: a replication and extension.

  • I. Bennun
  • Psychology
    Behaviour research and therapy
  • 1980

Catatonia in Obsessive-compulsive Disorder: Etiopathogenesis, Differential Diagnosis, and Clinical Management

The development of a systematic therapeutic plan for patients with OCD and comorbid catatonia includes the fine-tuning of the antiobsessional treatment; management ofComorbid disorders that may engender cat atonia; prompt discontinuation, and subsequent slow reintroduction of drugs deemed to trigger toxic reactions or to worsen comorbrid disorders and, ultimately, the catatonian.