Revisiting the Role of Interleukin-1 Pathway in Osteoarthritis: Interleukin-1α and -1β, and NLRP3 Inflammasome Are Not Involved in the Pathological Features of the Murine Menisectomy Model of Osteoarthritis

@inproceedings{Nasi2017RevisitingTR,
  title={Revisiting the Role of Interleukin-1 Pathway in Osteoarthritis: Interleukin-1α and -1β, and NLRP3 Inflammasome Are Not Involved in the Pathological Features of the Murine Menisectomy Model of Osteoarthritis},
  author={Sonia Nasi and H. O. Ea and Alexander Kai Lik So and Nathalie Busso},
  booktitle={Front. Pharmacol.},
  year={2017}
}
Background: Innate immune response components such as toll-like receptors (TLRs) and NLRP3-inflammasome act in concert to increase IL-1α/β secretion by synovial macrophages. Previous results suggest that IL-1α/β could be an important mediator involved in the pathogenesis of osteoarthritis (OA). Objectives: The aim of our study was to evaluate the role of NLRP3, IL-1β, and IL-1α in the menisectomy (MNX) model of murine OA. Methods: Murine chondrocytes (CHs) and bone marrow-derived machrophages… CONTINUE READING
1
Twitter Mention

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 78 REFERENCES

NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2011
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

In vivo reduction

K. S. Santangelo, G. J. Nuovo, A. L. Bertone
  • 2012
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL