Revisiting the Identification and cDNA Cloning of T Cell-Replacing Factor/Interleukin-5

@article{Takatsu2014RevisitingTI,
  title={Revisiting the Identification and cDNA Cloning of T Cell-Replacing Factor/Interleukin-5},
  author={Kiyoshi Takatsu},
  journal={Frontiers in Immunology},
  year={2014},
  volume={5}
}
  • K. Takatsu
  • Published 23 November 2014
  • Biology
  • Frontiers in Immunology
This is a perspective based on the paper “Cloning of complementary DNA encoding T cell-replacing factor and identity with B cell growth factor II,” by Kinashi et al. (1). We have been interested in understanding the molecular basis of T–B cell cooperation for antibody formation. Although many investigators had described a number of different soluble factors that appeared to have biological relevance to T–B cell interactions, molecular basis of such active substances remained unknown for a long… 
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References

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TLDR
To elucidate the molecular properties of TRF, cDNA encoding TRF was isolated from the 2.19 T-cell line and report here the structure and multiple activities of this lymphokine.
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TLDR
The molecular cloning, structural analysis and functional expression of the cDNA encoding human B SF-2 indicated that BSF-2 is functionally and structurally unlike other known proteins.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
The translation product of murine TRF/IL-5 cDNA triggers resting as well as activated murine B cells for terminal differentiation into Ig-secreting cells (IgM, IgG1, or IgA) accompanied by increased mRNA expression for secreted forms of relevant Ig heavy chain (mu, gamma, or alpha).
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TLDR
It is suggested that B cells can be triggered by at least two distinct helper T cell subpopulations via respective pathways (cognate interaction and factor-mediated interaction) and at least three distinctly functioning PPD-reactive helper T Cells can be generated by active immunization with Tbc in vivo.
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