Revisiting the Helical Cooperativity of Synthetic Polypeptides in Solution.


Using synthetic polypeptides as a model system, the theories of helix-coil transition were developed into one of the most beautiful and fruitful subjects in macromolecular science. The classic models proposed by Schellman and Zimm-Bragg more than 50 years ago, differ in the assumption on whether the configuration of multiple helical sequences separated by… (More)
DOI: 10.1021/acs.biomac.7b00534