Revisiting the Evidence for Neuropathy Caused by Pyridoxine Deficiency and Excess

  title={Revisiting the Evidence for Neuropathy Caused by Pyridoxine Deficiency and Excess},
  author={A Alavian Ghavanini and Kurt Kimpinski},
  journal={Journal of Clinical Neuromuscular Disease},
Abstract Pyridoxine deficiency and excess have been implicated as a cause for peripheral neuropathy. As a result, unrelated neuropathies are often treated with pyridoxine based on questionable evidence. However, neurological practitioners frequently discourage patients from taking pyridoxine in excess of 50 mg/d given concerns around the development of a toxic sensory neuronopathy. There is no systematic review to support either of the 2 practices. To address this gap in knowledge, we reviewed… 

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Low pyridoxine levels can be present in Patients with peripheral neuropathy irrespective of nutritional status especially in patients with sensory symptoms without weakness and with normal propioception.

Motor and sensory neuropathy secondary to excessive pyridoxine ingestion.

An 81-year-old woman admitted to the hospital because of difficulty in walking and frequent falls and nerve conduction studies revealed slowing of motor conduction velocities, prolonged F wave latencies, and prolonged sensory latencies in both lower extremities, indicating pyridoxine neurotoxicity.

Motor and sensory neuropathy secondary to excessive pyridoxine ingestion.

  • F. Foca
  • Medicine, Psychology
    Archives of physical medicine and rehabilitation
  • 1985
This report documents a case of mixed motor and sensory neuropathy that resulted from ingestion of excessive amounts of pyridoxine, and suggests that treatment of carpal tunnel syndrome with oral pyridine be carefully monitored and that dosage limits not be exceeded.

Sensory neuropathy with low‐dose pyridoxine

In all patients with adequate follow-up, improvement followed discontinuation of pyridoxine, and the ready availability of up to 1-gram tablets makes it likely that this neuropathy will be seen.

Electrophysiological Characteristics of Peripheral Neuropathy in Patients with Vitamin B6 Deficiency (P01.138)

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Acute sensory neuropathy‐neuronopathy from pyridoxine overdose

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Demonstration that pantothenic acid or pyridoxine deficiency may cause peripheral nerve dysfunction suggests that lack of these or other B-complex vitamins may also contribute to neuropathy in the malnourished alcoholic.

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