Revisiting the ERK/Src cortactin switch.

@article{Kelley2011RevisitingTE,
  title={Revisiting the ERK/Src cortactin switch.},
  author={Laura C. Kelley and Karen E. Hayes and Amanda Gatesman Ammer and Karen H. Martin and Scott A. Weed},
  journal={Communicative & integrative biology},
  year={2011},
  volume={4 2},
  pages={
          205-7
        }
}
The filamentous (F)-actin regulatory protein cortactin plays an important role in tumor cell movement and invasion by promoting and stabilizing actin related protein (Arp)2/3-mediated actin networks necessary for plasma membrane protrusion. Cortactin is a substrate for ERK1/2 and Src family kinases, with previous in vitro findings demonstrating ERK1/2 phosphorylation of cortactin as a positive and Src phosphorylation as a negative regulatory event in promoting Arp2/3 activation through neuronal… CONTINUE READING
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