Revisiting nicotine’s role in the ageing brain and cognitive impairment

  title={Revisiting nicotine’s role in the ageing brain and cognitive impairment},
  author={Alireza Majdi and Farzin Kamari and Manouchehr Seyedi Vafaee and S. Sadigh-Eteghad},
  journal={Reviews in the Neurosciences},
  pages={767 - 781}
Abstract Brain ageing is a complex process which in its pathologic form is associated with learning and memory dysfunction or cognitive impairment. During ageing, changes in cholinergic innervations and reduced acetylcholinergic tonus may trigger a series of molecular pathways participating in oxidative stress, excitotoxicity, amyloid-β toxicity, apoptosis, neuroinflammation, and perturb neurotrophic factors in the brain. Nicotine is an exogenous agonist of nicotinic acetylcholine receptors… 

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