Revisiting depressive-prone bipolar disorder: polarity of initial mood episode and disease course among bipolar I systematic treatment enhancement program for bipolar disorder participants.

@article{Perlis2005RevisitingDB,
  title={Revisiting depressive-prone bipolar disorder: polarity of initial mood episode and disease course among bipolar I systematic treatment enhancement program for bipolar disorder participants.},
  author={Roy H. Perlis and Melissa P. Delbello and Sachiko Miyahara and Stephen R. Wisniewski and Gary S. Sachs and Andrew Nierenberg},
  journal={Biological psychiatry},
  year={2005},
  volume={58 7},
  pages={549-53}
}
BACKGROUND We examined the hypothesis that a first depressive rather than manic episode in bipolar disorder might herald a subsequent course notable for greater burden of depressive symptoms. METHODS We analyzed retrospective data on the polarity of first mood episode obtained from 704 bipolar I subjects entering the multicenter Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) study. Subjects with an initial manic or depressive episode and those in whom both poles… CONTINUE READING

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