Revisiting de novo drug design: receptor based pharmacophore screening.

@article{Amaravadhi2014RevisitingDN,
  title={Revisiting de novo drug design: receptor based pharmacophore screening.},
  author={Harikishore Amaravadhi and Kwanghee Baek and Ho Sup Yoon},
  journal={Current topics in medicinal chemistry},
  year={2014},
  volume={14 16},
  pages={
          1890-8
        }
}
De novo drug design methods such as receptor or protein based pharmacophore modeling present a unique opportunity to generate novel ligands by employing the potential binding sites even when no explicit ligand information is known for a particular target. Recent developments in molecular modeling programs have enhanced the ability of early programs such as… CONTINUE READING