Revisiting bone targeting potential of novel hydroxyapatite based surface modified PLGA nanoparticles of risedronate: Pharmacokinetic and biochemical assessment.

@article{Rawat2016RevisitingBT,
  title={Revisiting bone targeting potential of novel hydroxyapatite based surface modified PLGA nanoparticles of risedronate: Pharmacokinetic and biochemical assessment.},
  author={Purnima Rawat and Iqbal Ahmad and Shindu C Thomas and Shweta Pandey and Divya Vohora and Sarika Gupta and Farhan Jalees Ahmad and Sushama Talegaonkar},
  journal={International journal of pharmaceutics},
  year={2016},
  volume={506 1-2},
  pages={253-61}
}
Hydroxyapatite based biodegradable mPEG-PLGA nanoparticles of risedronate (mPEG-PLGA-RIS-HA) were prepared by water miscible dialysis method for synergistic treatment of osteoporosis. The bone targeting potential of prepared nanoparticles was evaluated by performing the cell viability study and protein estimation in pre-osteoblast cell line (MC3T3E1). Biochemical and in-vivo pharmacokinetic studies on osteoporotic rat model treated with different formulations were performed. Under the… CONTINUE READING