Revisiting an old antimicrobial drug: amphotericin B induces interleukin-1-converting enzyme as the main factor for inducible nitric-oxide synthase expression in activated endothelia.

@article{Suschek2002RevisitingAO,
  title={Revisiting an old antimicrobial drug: amphotericin B induces interleukin-1-converting enzyme as the main factor for inducible nitric-oxide synthase expression in activated endothelia.},
  author={Christoph Viktor Suschek and Eckhard Bonmann and Anna Kapsokefalou and Karsten Hemmrich and Hartmut Kleinert and Ulrich Foerstermann and K D Kr{\"o}ncke and Csaba Mahotka and Victoria Kolb-Bachofen},
  journal={Molecular pharmacology},
  year={2002},
  volume={62 4},
  pages={936-46}
}
We have investigated the impact of the widely used antifungal agent Amphotericin B (AmB) on cytokine activated aortic endothelial cells (AEC) and their inflammatory response as monitored by cytokine and inducible nitric-oxide synthase (iNOS) expression as well as high-output nitric oxide synthesis. Because both blood-borne infections and systemically administered drugs will first encounter vessel lining endothelial cells, this cell type represents an important participant in innate immune… CONTINUE READING

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