Revisiting Estimates of CTL Killing Rates In Vivo

@article{Yates2007RevisitingEO,
  title={Revisiting Estimates of CTL Killing Rates In Vivo},
  author={Andrew Yates and Frederik Graw and Daniel L Barber and Rafi Ahmed and Roland R. Regoes and Rustom Antia},
  journal={PLoS ONE},
  year={2007},
  volume={2},
  pages={1652 - 6}
}
Recent experimental advances have allowed the estimation of the in vivo rates of killing of infected target cells by cytotoxic T lymphocytes (CTL). We present several refinements to a method applied previously to quantify killing of targets in the spleen using a dynamical model. We reanalyse data previously used to estimate killing rates of CTL specific for two epitopes of lymphocytic choriomeningitis virus (LCMV) in mice and show that, contrary to previous estimates the "killing rate" of… CONTINUE READING

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