Revisiting Brain Atrophy and Its Relationship to Disability in Multiple Sclerosis

@inproceedings{Shiee2012RevisitingBA,
  title={Revisiting Brain Atrophy and Its Relationship to Disability in Multiple Sclerosis},
  author={Navid Shiee and Pierre-Louis Bazin and Kathleen M. Zackowski and Sheena K. Farrell and Daniel M. Harrison and Scott D. Newsome and John N. Ratchford and B. S. Caffo and Peter A. Calabresi and Dzung L. Pham and Daniel S. Reich},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Brain atrophy is a well-accepted imaging biomarker of multiple sclerosis (MS) that partially correlates with both physical disability and cognitive impairment. METHODOLOGY/PRINCIPAL FINDINGS Based on MRI scans of 60 MS cases and 37 healthy volunteers, we measured the volumes of white matter (WM) lesions, cortical gray matter (GM), cerebral WM, caudate nucleus, putamen, thalamus, ventricles, and brainstem using a validated and completely automated segmentation method. We correlated… CONTINUE READING