Revisiting AMPA Receptors as an Antiepileptic Drug Target

@article{Rogawski2011RevisitingAR,
  title={Revisiting AMPA Receptors as an Antiepileptic Drug Target},
  author={Michael A. Rogawski},
  journal={Epilepsy Currents},
  year={2011},
  volume={11},
  pages={56 - 63}
}
  • M. Rogawski
  • Published 1 March 2011
  • Biology, Psychology, Medicine
  • Epilepsy Currents
In the 1990s there was intense interest in ionotropic glutamate receptors as therapeutic targets for diverse neurological disorders, including epilepsy. NMDA receptors were thought to play a key role in the generation of seizures, leading to clinical studies of NMDA receptor blocking drugs in epilepsy. Disappointing results dampened enthusiasm for ionotropic glutamate receptors as a therapeutic target. Eventually it became appreciated that another type of ionotropic glutamate receptor, the AMPA… 

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The data raised from the studies can give a hope that perampanel offers a valuable option as an adjuvant therapy for pharmacoresistant partial‐onset and secondarily generalized seizures.

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  • Medicine, Psychology
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  • 2015
Perampanel is the first-in-class orally active, selective, noncompetitive antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and the pharmacokinetic profile offers once-daily dosing in the evening as the best route of administration.
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