Revisiting AMPA Receptors as an Antiepileptic Drug Target
@article{Rogawski2011RevisitingAR, title={Revisiting AMPA Receptors as an Antiepileptic Drug Target}, author={Michael A. Rogawski}, journal={Epilepsy Currents}, year={2011}, volume={11}, pages={56 - 63} }
In the 1990s there was intense interest in ionotropic glutamate receptors as therapeutic targets for diverse neurological disorders, including epilepsy. NMDA receptors were thought to play a key role in the generation of seizures, leading to clinical studies of NMDA receptor blocking drugs in epilepsy. Disappointing results dampened enthusiasm for ionotropic glutamate receptors as a therapeutic target. Eventually it became appreciated that another type of ionotropic glutamate receptor, the AMPA…
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