Revisited physicochemical and transport properties of respiratory mucus in genotyped cystic fibrosis patients.

@article{Deneuville1997RevisitedPA,
  title={Revisited physicochemical and transport properties of respiratory mucus in genotyped cystic fibrosis patients.},
  author={Eric Deneuville and C. Perrot-Minot and François Pennaforte and Michel Roussey and Jean-Marie Zahm and Christine Clavel and Edith Puchelle and Sophie de Bentzmann},
  journal={American journal of respiratory and critical care medicine},
  year={1997},
  volume={156 1},
  pages={
          166-72
        }
}
We investigated the physicochemical and transport properties of sputum samples collected in physiotherapy from a well-documented group of 27 cystic fibrosis (CF) patients with identified CF genotypes. Sputum samples were characterized ex vivo for their water content, surface properties (surface tension and contact angle), rheologic properties (viscosity and elastic modulus), and transport properties (mucociliary and cough transport). These data were analyzed in relation to the clinical status… 
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Improvement of cystic fibrosis airway mucus transportability by recombinant human DNase is related to changes in phospholipid profile.
TLDR
It is suggested that rhDNase is able to increase the free water content and alter the phospholipid profile of mucus, with a related improvement in CF mucus transportability.
Adhesiveness and purulence of respiratory secretions: implications for mucociliary transport in patients with bronchiectasis.
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The respiratory secretions of patients with bronchiectasis showed decreased mucociliary transport, and increased adhesiveness and purulence cause the worsening of transport properties, as demonstrated by the lesser displacement in the SCM and the higher CA.
A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms
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It is suggested that the thickened mucus gel model will be useful to develop therapies of P. aeruginosa biofilms in CF via changes in the hydration-dependent physical–chemical properties of mucus and to link airway surface liquid hyperabsorption to the high incidence of the disease.
Macrorheology of cystic fibrosis, chronic obstructive pulmonary disease & normal sputum
TLDR
It is shown that CF sputum viscoelasticity is related to secondary infection, decreases with intravenous antibiotic therapy and correlates with inflammation, and COPDSputum demonstrates inherently greater viscoleasticity, providing a novel target for potential therapeutic interventions.
Physicochemical properties of human tracheobronchial sputum maintained at room temperature.
TLDR
Haline tracheobronchial sputum can be stored in room temperature for 24 h without presenting alterations in ciliary transport or contact angle, however, purulent sputums should not be stored at roomTemperature for many hours, since ciliary Transport and contact angle might be altered as a result.
Pulmonary function is negatively correlated with sputum inflammatory markers and cough clearability in subjects with cystic fibrosis but not those with chronic bronchitis.
TLDR
The sputum concentrations of IL-8, MPO, and DNA appear to be closely associated with pulmonary function inSubjects with CF but not in subjects with CB, and there was no correlation among pulmonary function,Sputum properties, and inflammatory markers in the sputums from subjects withCB.
Mucus properties in children with primary ciliary dyskinesia: comparison with cystic fibrosis.
TLDR
It is unlikely that established CF lung disease is principally due to abnormal sputum properties, and it is more likely that the biophysical and transport properties reflect disease severity regardless of whether bronchiectasis is due to CF or PCD.
The Influence of Purulence on Ciliary and Cough Transport in Bronchiectasis
TLDR
Respiratory secretions in individuals with bronchiectasis have poor transport properties, which manifest as reduced mucociliary transport, reduced mucus transport by cough, and higher contact angle.
Ion composition and rheology of airway liquid from cystic fibrosis fetal tracheal xenografts.
TLDR
The results suggest that prior to inflammation and infection, the viscosity and ion composition of the fetal AL do not differ in CF and non-CF.
The effect of Pseudomonas aeruginosa infection on clinical parameters in steady-state bronchiectasis.
TLDR
P aeruginosa is the predominant respiratory pathogen isolated in the sputum of Chinese patients with steady-state bronchiectasis, and its isolation is associated with highSputum output (> or = 75th quartile) and moderately severe airflow obstruction (FEV1/FVC < 60%).
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