Revisited and revised: is RhoA always a villain in cardiac pathophysiology?

  title={Revisited and revised: is RhoA always a villain in cardiac pathophysiology?},
  author={Shigeki Miyamoto and Dominic P. Del Re and Sunny Yang Xiang and Xia Zhao and Geir Florholmen and Joan Brown},
  journal={Journal of cardiovascular translational research},
  volume={3 4},
The neonatal rat ventricular myocyte model of hypertrophy has provided tremendous insight with regard to signaling pathways regulating cardiac growth and gene expression. Many mediators thus discovered have been successfully extrapolated to the in vivo setting, as assessed using genetically engineered mice and physiological interventions. Studies in neonatal rat ventricular myocytes demonstrated a role for the small G-protein RhoA and its downstream effector kinase, Rho-associated coiled-coil… CONTINUE READING


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p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13

  • T. Kozasa, X. Jiang, +4 authors G A.
  • 1998
Highly Influential
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