Revisit dietary fiber on colorectal cancer: butyrate and its role on prevention and treatment

@article{Encarnao2015RevisitDF,
  title={Revisit dietary fiber on colorectal cancer: butyrate and its role on prevention and treatment},
  author={Jo{\~a}o Crispim Encarnaç{\~a}o and Ana Margarida Coelho Abrantes and Ana Salom{\'e} Pires and Maria Filomena Botelho},
  journal={Cancer and Metastasis Reviews},
  year={2015},
  volume={34},
  pages={465-478}
}
Colorectal cancer is still a major health problem worldwide. Based on the most recent released data by the World Health Organization GLOBOCAN in 2012, colorectal cancer is the third most prevalent type of cancer in males and the second in females. In 1999, it was published the first report showing evidence of a strong correlation between diet and cancer incidence, being its positive or negative impact intimately linked to dietary patterns. A diet rich in fiber is associated with a low risk of… 

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References

SHOWING 1-10 OF 118 REFERENCES

A review of the potential mechanisms for the lowering of colorectal oncogenesis by butyrate

TLDR
The mechanisms involved in butyrate-induced apoptosis in CRC cells are reviewed and the potential role this SCFA may play in mediating key processes in tumorigenesis including genomic instability, inflammation and cell energy metabolism is considered.

Microbial degradation products influence colon cancer risk: the butyrate controversy.

TLDR
The studies suggest that the chemopreventive benefits of butyrate depend in part on amount, time of exposure with respect to the tumorigenic process, and the type of fat in the diet.

Butyrate and colorectal cancer: the role of butyrate transport.

TLDR
The mechanisms of BT transport are discussed and this knowledge is integrated with the effects of BT in tumoral and normal colonocytes and the "BT paradox" is integrated.

Diet and supplements and their impact on colorectal cancer.

TLDR
It is found that diets rich in Folate may prevent colorectal carcinoma and the lack of randomized trials and the presence of confounding factors including smoking, physical activity, obesity and diabetes may often yield inconclusive results.

Molecular mechanisms for chemoprevention of colorectal cancer by natural dietary compounds.

TLDR
This review focuses on preventing the initiation and promotion of neoplastic growth in colorectal cancer, particularly with natural dietary compounds, by providing evidence for these substances in colonic cancer chemopreventive action.

In vitro studies on the inhibition of colon cancer by butyrate and carnitine.

Butyrate: implications for intestinal function

TLDR
This review examines the recent findings regarding the role and mechanisms by which butyrate regulates intestinal metabolism and discusses how these findings could improve the treatment of several gastrointestinal disorders.

The Role of Intestinal Microbiota in Development of Irinotecan Toxicity and in Toxicity Reduction through Dietary Fibres in Rats

CPT-11 is a drug used as chemotherapy for colorectal cancer. CPT-11 causes toxic side-effects in patients. CPT-11 toxicity has been attributed to the activity of intestinal microbiota, however,

Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention.

TLDR
The current knowledge concerning the mechanisms via which dietary fiber protects against colon cancer is reviewed.
...