Revision of the International Neuroblastoma Pathology Classification

  title={Revision of the International Neuroblastoma Pathology Classification},
  author={Michel Peuchmaur and Emanuele S G d'Amore and VijayV. Joshi and Jun-Ichi Hata and Borghild Roald and Louis P. Dehner and Robert B. Gerbing and Daniel O. Stram and John N Lukens and Katherine K. Matthay and Hiroyuki Shimada},
BACKGROUND Ganglioneuroblastoma, nodular (GNBn) comprises one of the categories of peripheral neuroblastic tumors. [] Key MethodRESULTS The review clarified and illustrated morphologic characteristics of classical GNBn and it variants. The diagnosis of GNBn was confirmed in 67 of 70 patients. There were 22 patients with GNBn in the FS and 45 patients with GNBn in the US.
[Pathology of peripheral neuroblastic tumors].
In this article, prognostic significance and biological relevance of the International Neuroblastoma Pathology Classification (INPC) are described.
Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: A report from the CCG and COG
The International Neuroblastoma Pathology Classification (INPC) was the first to clearly define prognostic subgroups in ganglioneuroma (GN) and ganglioneuroblastoma (GNB).
Neuroblastoma and Related Tumors
5 peripheral neuroblastic tumors are presented and the prognostic significance and biologic relevance of the International Neuroblastoma Pathology Classification (INPC) are illustrated.
Two cases of neuroblastoma comprising two distinct clones
We report two cases of high‐risk metastatic neuroblastoma, comprising two biologically distinct components in the adrenal primary tumor, which showed clear differences not only histologically but
Neuroblastoma: Tumor Biology and Its Implications for Staging and Treatment
Current biologic principles used to stratify risk and guide treatment algorithms are discussed and the role for surgical resection in neuroblastoma is reviewed, including the indications and timing of surgery within the greater treatment plan.
Pediatric solid malignancies: neuroblastoma and Wilms' tumor.
Adult onset of ganglioneuroblastoma of the adrenal gland: case report and review of the literature
The case of a 63-year-old man affected by ganglioneuroblastoma of the adrenal gland is presented and the tumor, measuring 5 × 3 cm, was successfully surgically removed.
Neuroblastoma in an adult: case presentation and literature review.
A case of neuroblastoma is presented in a 39-year-old woman who failed to respond to intensive therapy for this malignancy and died within a year after diagnosis.
Update on neuroblastoma.


The International Neuroblastoma Pathology Classification (the Shimada system)
The International Neuroblastoma Pathology Committee, which is comprised of six member pathologists, was convened with the objective of proposing a prognostically significant and biologically relevant
Histopathology defines prognostic subsets of ganglioneuroblastoma, nodular
Ganglioneuroblastoma, nodular (GNBn) is a rare subtype of the family of neuroblastic tumors that are classified in the unfavorable histology group according to the International Neuroblastoma Pathology Classification (Shimada system).
Terminology and morphologic criteria of neuroblastic tumors
As part of the international cooperative effort to develop a complete set of International Neuroblastoma Risk Groups, the International Neuroblastoma Pathology Committee (INPC) initiated activities
International neuroblastoma pathology classification for prognostic evaluation of patients with peripheral neuroblastic tumors
The International Neuroblastoma Pathology Classification was established in 1999 for the prognostic evaluation of patients with neuroblastic tumors (NTs).
Ganglioneuroblastoma of the posterior mediastinum: A clinicopathologic review of 80 cases
The pathology and clinical course of 80 cases of ganlioneuroblastoma (GNB) of the posterior mediastinum are presented and the therapeutic implications and need for uniform terminology in classifying GNBs are discussed.
Histopathologic prognostic factors in neuroblastic tumors: definition of subtypes of ganglioneuroblastoma and an age-linked classification of neuroblastomas.
Histopathologic prognostic factors of 295 pretreatment tumors of a total 641 neuroblastomas and ganglioneuroblastomas were studied with the use of the following proposed tumor classification. The
Recommendations for modification of terminology of neuroblastic tumors and prognostic significance of Shimada classification. A clinicopathologic study of 213 cases from the pediatric oncology group
The results showed that, even after stratification for age, POG stage, and primary site, there is a statistically significant difference in survival rate between favorable histologic and unfavorable histologic prognostic subgroups.
Conventional versus modified morphologic criteria for ganglioneuroblastoma. A review of cases from the Pediatric Oncology Group.
It is recommended that the term GNB should be used both clinically and pathologically to designate a distinctive subgroup of neuroblastic tumors, in contrast to the current use, which designates both NB and GNB.
The International Neuroblastoma Pathology Classification.
Successful treatment of stage III neuroblastoma based on prospective biologic staging: a Children's Cancer Group study.
  • K. MatthayC. Perez J. Lukens
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1998
The excellent survival of the biologically favorable group and the historically improved EFS of the biological unfavorable group suggest that biologic staging should be used to define the prognosis and treatment of stage III neuroblastoma.