Revising B Cell Receptors

  title={Revising B Cell Receptors},
  author={David Nemazee and Martin Weigert},
  journal={The Journal of Experimental Medicine},
  pages={1813 - 1818}
B cell development is often portrayed as a series of decision points that expand an antigen-reactive cell to a clone producing a single antibody. This is hardly the case: B cell development is dependent on a series of error-prone, random rearrangement events that through ongoing diversification reach a compromise in which most cells are not au-toreactive (except in disease) and the majority of clone members remain specific for the initial antigen. One familiar example of ongoing diversification… CONTINUE READING
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