Revised structure, total synthesis, and absolute configuration of kopeolin and kopeolone.

@article{Miquet2014RevisedST,
  title={Revised structure, total synthesis, and absolute configuration of kopeolin and kopeolone.},
  author={St{\'e}phanie Miquet and Paul Br{\'e}mond and Benjamin Ayela and S. Marque and G. Audran},
  journal={The Journal of organic chemistry},
  year={2014},
  volume={79 5},
  pages={
          2268-73
        }
}
An enantioselective total synthesis of two sesquiterpenoids, kopeolin and kopeolone, has been achieved. Using the diastereoselective addition of an organocerate as a key step, we controlled the absolute stereochemistry of a crucial stereocenter present in these natural products. This approach allowed us to confirm a structural revision that we previously proposed (Chem.-Eur. J. 2013, 19, 10632-10642) and to fully characterize these natural products while elucidating their absolute… Expand
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