Revised risk estimation and treatment stratification of low- and intermediate-risk neuroblastoma patients by integrating clinical and molecular prognostic markers.

@article{Oberthuer2015RevisedRE,
  title={Revised risk estimation and treatment stratification of low- and intermediate-risk neuroblastoma patients by integrating clinical and molecular prognostic markers.},
  author={Andr{\'e} Oberthuer and Dilafruz Juraeva and Barbara Hero and Roscoe H. Volland and Carolina M Sterz and Ren{\'e} W. Schmidt and Andreas Faldum and Yvonne Kahlert and Anne Engesser and Shahab Asgharzadeh and R. Seeger and Miki Ohira and Akira Nakagawara and Paola Scaruffi and Gian Paolo Tonini and Isabelle Janoueix-Lerosey and Olivier Delattre and Jo Vandesompele and Frank Speleman and Rosa Noguera and Marta Piqueras and Jean B{\'e}nard and Alexander A Valent and Smadar Avigad and Isaac Yaniv and Richard G. Grundy and Monika Ortmann and Chunxuan Shao and Manfred Schwab and Roland Eils and Thorsten Simon and Jessica Thei{\ss}en and Frank Berthold and Frank Westermann and Benedikt Brors and Matthias Hermann Fischer},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2015},
  volume={21 8},
  pages={
          1904-15
        }
}
PURPOSE To optimize neuroblastoma treatment stratification, we aimed at developing a novel risk estimation system by integrating gene expression-based classification and established prognostic markers. EXPERIMENTAL DESIGN Gene expression profiles were generated from 709 neuroblastoma specimens using customized 4 × 44 K microarrays. Classification models were built using 75 tumors with contrasting courses of disease. Validation was performed in an independent test set (n = 634) by Kaplan-Meier… CONTINUE READING
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Molecular characterization and classification of neuroblastoma

  • A Oberthuer, J Theissen, F Westermann, B Hero, M. Fischer
  • Future Oncol ;
  • 2009
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