Revised response criteria for polycythemia vera and essential thrombocythemia: an ELN and IWG-MRT consensus project.

@article{Barosi2013RevisedRC,
  title={Revised response criteria for polycythemia vera and essential thrombocythemia: an ELN and IWG-MRT consensus project.},
  author={Giovanni Barosi and Ruben A. Mesa and Guido Finazzi and Claire Harrison and Jean-Jacques Kiladjian and Eva Lengfelder and Mary Frances McMullin and Francesco Passamonti and Alessandro Maria Vannucchi and Carlos Besses and Heinz Gisslinger and Jan Samuelsson and Srdan Verstovsek and Ronald F. Hoffman and Animesh Pardanani and Francisco Cervantes and Ayalew Tefferi and Tiziano Barbui},
  journal={Blood},
  year={2013},
  volume={121 23},
  pages={4778-81}
}
Standardized response criteria to interpret and compare clinical trials are needed for approval of new therapeutic agents by regulatory agencies. The European LeukemiaNet (ELN) response criteria for essential thrombocythemia (ET) and polycythemia vera (PV) issued in 2009 have been widely adopted as end points in a number of recent clinical trials. However, evidence exists that they do not predict response or provide clinically relevant measures of benefit for the patients. This article presents… CONTINUE READING

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