Revised Structures of Epohelmins A and B Isolated as Lanosterol Synthase Inhibitors from a Fungal Strain FKI-0929

Abstract

The structures of epohelmins A and B isolated as lanosterol synthase inhibitors from a fungal strain FKI-0929 were revised to be 1α-hydroxy-3α-(4′-oxoundec-(5′E)-enyl)-pyrrolizidine and 1β-hydroxy-3α-(4′-oxoundec-(5′E)-enyl)-pyrrolizidine, respectively, by comparison with spectral data of synthetic compounds.

DOI: 10.1038/ja.2005.82

Cite this paper

@article{Shibuya2005RevisedSO, title={Revised Structures of Epohelmins A and B Isolated as Lanosterol Synthase Inhibitors from a Fungal Strain FKI-0929}, author={Masaaki Shibuya and Barry B. Snider and Yuichi Sakano and Hiroshi Tomoda and Satoshi O̅mura and Yutaka Ebizuka}, journal={The Journal of Antibiotics}, year={2005}, volume={58}, pages={599-601} }