Reviewing biophysical and cell biological methodologies in cell-penetrating peptide (CPP) research.

@article{Herbig2007ReviewingBA,
  title={Reviewing biophysical and cell biological methodologies in cell-penetrating peptide (CPP) research.},
  author={Michael E Herbig and Kathrin M. Weller and Hans Peter Merkle},
  journal={Critical reviews in therapeutic drug carrier systems},
  year={2007},
  volume={24 3},
  pages={203-55}
}
The discovery of cell-penetrating peptides (CPPs), which have the ability to translocate across the plasma membranes of mammalian cells, has led to widespread optimism for delivery of problematic therapeutic cargoes to cells. These cargoes include peptide, protein, and nucleic acid biopharmaceuticals and even nano-sized vectors such as liposomes and nanoparticles. Research on CPPs includes biophysical studies of membrane models to investigate fundamental principles of CPP-lipid membrane… CONTINUE READING