ReviewPart of the Series: From Dietary Antioxidants to Regulators in Cellular Signalling and Gene ExpressionReview: When is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin C

@article{Duarte2005ReviewPartOT,
  title={ReviewPart of the Series: From Dietary Antioxidants to Regulators in Cellular Signalling and Gene ExpressionReview: When is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin C},
  author={T. Duarte and J. Lunec},
  journal={Free Radical Research},
  year={2005},
  volume={39},
  pages={671 - 686}
}
  • T. Duarte, J. Lunec
  • Published 2005
  • Biology, Medicine
  • Free Radical Research
  • Vitamin C (or ascorbic acid) is regarded as the most important water-soluble antioxidant in human plasma and mammalian cells which have mechanisms to recycle and accumulate it against a concentration gradient, suggesting that the vitamin might also have important intracellular functions. In this review we summarize evidence from human trials that have attempted an association between vitamin C supplementation and an effect on biomarkers of oxidative DNA damage. Most studies reviewed herein… CONTINUE READING
    304 Citations
    Vitamin C: update on physiology and pharmacology
    • 307
    • Highly Influenced
    Vitamin C in Cultured Human (HeLa) Cells: Lack of Effect on DNA Protection and Repair
    • 20
    • PDF
    Effects of vitamin C on health: a review of evidence.
    • 117
    • Highly Influenced
    • PDF
    Effects of acute oral administration of vitamin C on the mouse liver transcriptome.
    • 10
    • PDF
    A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives.
    • Márcio Carocho, I. C. Ferreira
    • Biology, Medicine
    • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
    • 2013
    • 944
    • PDF
    Vitamin C: An Antioxidant Agent
    • 22
    • PDF
    Vitamin C modulation of H2O2-induced damage and iron homeostasis in human cells.
    • 56
    • PDF
    Plant-Derived Compounds as Antioxidants for Health - Are They all Really Antioxidants?
    • 10
    • PDF

    References

    SHOWING 1-10 OF 144 REFERENCES
    Vitamin C and genomic stability.
    • 182
    Does vitamin C act as a pro‐oxidant under physiological conditions?
    • A. Carr, B. Frei
    • Medicine, Biology
    • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
    • 1999
    • 766
    Novel repair action of vitamin C upon in vivo oxidative DNA damage
    • 225
    The effect of vitamin C or vitamin E supplementation on basal and H2O2-induced DNA damage in human lymphocytes.
    • 108
    • PDF
    Vitamin C-Induced Decomposition of Lipid Hydroperoxides to Endogenous Genotoxins
    • 387
    New evidence for antioxidant properties of vitamin C.
    • 47
    Vitamin C supplementation decreases oxidative DNA damage in mononuclear blood cells of smokers
    • 83
    • PDF