Corpus ID: 34226937

Review study on lactoferrin : A multifunctional protein

  title={Review study on lactoferrin : A multifunctional protein},
  author={S. Nazir and M. Nasir and Ammara Yasmeen and S. Usman},
Lactoferrin is a glycoprotein of 703 amino acids originally isolated from milk. Lactoferrin exists in body fluids and can be found in the form of free iron, monoferric and diferic form. Scientist also found lactoferrin in the secretions of mammal’s pancreas, and in secondary neutrophil granules. Lactoferrin has wide range of functions which may range from binding of Lactoferrin with iron, in control of the availability of an enhanced immune system and as a strong bacteriostatic agent, but the… Expand
Polysialic Acid Modulates the Binding of External Lactoferrin in Neutrophil Extracellular Traps
PolySia initiates the incorporation of external lactoferrin in already-loaded NETs and may modulate the constituents of NET, as demonstrated in experiments with NET fibers saturated with lact oferrin. Expand
The Impact of Lactoferrin on the Growth of Intestinal Inhabitant Bacteria
By using Lf as a component in pharmacological products, this contribution may enable novel strategies that promote probiotic growth while conferring antimicrobial activity against multidrug-resistant microorganisms that cause life-threatening diseases, especially in neonates. Expand
Spectroscopic and Molecular Modeling Investigation on the Interaction between Folic Acid and Bovine Lactoferrin from Encapsulation Perspectives
The obtained results support the suitability of LF as biocompatible material, for obtaining micro- and nanoparticles for delivery of dietary supplements or for enhancing the functionality of target delivery systems. Expand


Lactoferrin: a general review.
A wide spectrum of functions are ascribed to lactoferrin, which range from a role in the control of iron availability to immune modulation, and more research is necessary to obtain clarity with regard to the exact mechanism of action. Expand
Multiple molecular forms of human lactoferrin. Identification of a class of lactoferrins that possess ribonuclease activity and lack iron- binding capacity
Lactoferrin, the major iron-binding component of milk, is shown to occur in three isoforms that express potent RNase activity, but do not bind iron. Expand
Multifunctional roles of lactoferrin: a critical overview.
Recent advances in the understanding of the functions of LF are discussed, including specific interactions with mammalian receptors and microbial components, and the pleoitropic functional nature of this protein. Expand
Lactoferrin in milk from different species.
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A comparison of the concentration of lact oferrin wiht that of iron, in milk from various mammals, failed to provide any grounds for the assumption of a direct role of lactoferrin in the excretion of iron into milk. Expand
Giardicidal activity of lactoferrin and N-terminal peptides.
These studies suggest that lactoferrin, especially in the form of the N-terminal peptides, may be an important nonimmune component of host mucosal defenses against Giardia lamblia. Expand
Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties.
This review covers the current state of research in this field of Lfcin, focusing on the many beneficial activities of this peptide, and the main site of action for the peptide may be intracellular. Expand
Effects of lactoferrin and lactoferricin on the release of interleukin 8 from human polymorphonuclear leukocytes.
A basic peptide, protamine, exerted the same effect as that of LF and LFcin, suggesting the importance of the basic nature of LFand LFcin in acting as an inducer of IL-8 release from PMNs. Expand
Lactoferricin derived from milk protein lactoferrin.
A comprehensive review of investigations of LFcin and related peptides is presented, shown to protect the host via direct antimicrobial activity and immunostimulatory effects in several infection models of mice. Expand
The hyposideremia of inflammation was found to be based on a three-step mechanism involving lactoferrin, the iron-binding protein from the specific granules of neutrophilic leukocytes, and the existence of specific receptors for Fe-lact oferrin on the membrane of macrophages is suggested. Expand
[Recent knowledge of the structure and function of lactoferrin and ferritin].
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  • Chemistry, Medicine
  • Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete
  • 1989
The ferritins are spherically constructed molecules which possess channels through which Fe-ions can be taken up or taken off and is dependent upon age as well as the Fe-supply. Expand