Review on alginate-based hydrogel bio-printing for application in tissue engineering.

  title={Review on alginate-based hydrogel bio-printing for application in tissue engineering.},
  author={Prasansha Rastogi and Balasubramanian Kandasubramanian},
The dawn of 3D printing in medicals has pinned the domain with hopes of vitality in many patients combating with multitude of diseases. Also entitled as Bio-printing, this is appertained to its sequential printing of precursor ink, embodying cells and polymer/composite, in predetermined trajectory. Precursor ink, in addition to cells, constitutes predominantly hydrogels ascribed to its biodegradability and mimic ability of body's anatomy and mechanical features, e.g. bones, etc. This review… 
A Study of the Printability of Alginate-Based Bioinks by 3D Bioprinting for Articular Cartilage Tissue Engineering
The results demonstrate that alginate microstructure has a great influence on its printability and on hydrogels’ physicochemical properties and suggest the importance of an exhaustive control of the viscoelastic and mechanical properties ofAlginate hydrogel to obtain structures with high resolution and precision.
Alginate and alginate composites for biomedical applications
Hybrid 3D Printing of Advanced Hydrogel-Based Wound Dressings with Tailorable Properties
This work shows that the novel hybrid hydrogel-thermoplastic scaffolds with adjustable characteristics have immense potential for tissue engineering and can serve as templates for developing novel wound dressings.
Hydrogel-Colloid Composite Bioinks for Targeted Tissue-Printing.
This Review offers a comprehensive picture of the role of colloids in bioprinting from a physicochemical and biological perspective and provides guidance on devising adaptable bioinks for the fabrication of biomimetic tissues.
A review on alginate-based bioinks, combination with other natural biomaterials and characteristics.
This review interprets the alginate-based bioink, focusing on its composite with other natural biomaterials, especially gelatin, and discusses the parameters that affect bioink functionality and cell viability.
Three-Dimensional Printable Hydrogel Using a Hyaluronic Acid/Sodium Alginate Bio-Ink
The results suggest that the 3D printable HA/SA hydrogel could be used as the bio-ink for tissue engineering applications.
3D-Reactive printing of engineered alginate inks.
A new perspective allowed 3D-reactive printing of alginate fibers with predetermined properties, without involving post-extrusion crosslinking steps and additives.
A targeted rheological bioink development guideline and its systematic correlation with printing behavior
An expandable concept for bioink development and a highly reproducible and well-characterized procedure for printing with the newly developed hydrogel, which provides detailed insights into the relationship between printing parameters, rheological parameters and short-term cultivation stability are presented.
Preparation and characterization of gelatin-polysaccharide composite hydrogels for tissue engineering
The gelatin-polysaccharide composite hydrogels could serve as attractive biomaterials for tissue engineering due to their easy preparation and favorable biophysical properties.


Bio-ink properties and printability for extrusion printing living cells.
Alginate (Alg) was selected as the major component of the 'bio-ink' formulations for extrusion printing of cells and the viability of primary myoblasts delivered as a myoblast/Alg-Gel bio-ink was not affected by the printing process, indicating that the Alg-gel matrix provides a potential means to print 3D constructs that may find application in myoregenerative applications.
A bioprintable form of chitosan hydrogel for bone tissue engineering.
It was shown for the first time that chitosan solution and its composite with nanostructured bone- like hydroxyapatite (HA) can be mixed with cells and printed successfully and it was proven that the presence of bone-like nanostructure HA in alginate and chitOSan hydrogels improved cell viability, proliferation and osteogenic differentiation.
3D Printability of Alginate-Carboxymethyl Cellulose Hydrogel
A novel hybrid hydrogel, that is, sodium alginate with carboxymethyl cellulose (CMC) is developed and systematic quantitative characterization tests are conducted to validate its printability, shape fidelity and cell viability and open an avenue directing reproducible printability and shape fidelity.
Applications of Alginate-Based Bioinks in 3D Bioprinting
  • E. Axpe, M. Oyen
  • Biology, Engineering
    International journal of molecular sciences
  • 2016
The benefits and disadvantages of the use of alginate in 3D bioprinting are discussed by summarizing the most recent studies that usedAlginate for printing vascular tissue, bone and cartilage, as well as other breakthroughs in the use in order to inspire and accelerate novel alginated bioink formulations with enhanced properties for future applications in basic research, drug screening and regenerative medicine.
Engineering alginate as bioink for bioprinting.
Development of a novel alginate-polyvinyl alcohol-hydroxyapatite hydrogel for 3D bioprinting bone tissue engineered scaffolds.
A novel alginate-polyvinyl alcohol (PVA)-hydroxyapatite (HA) hydrogel formulation with optimal rheological properties for 3D bioprinting of mouse calvaria 3T3-E1 cells into scaffolds of high shape fidelity has been developed.
Optimization of gelatin-alginate composite bioink printability using rheological parameters: a systematic approach.
A framework for evaluating printability was developed and the effect of dynamic modulus, including storage modulus (G'), loss modulus(G″), and loss tangent (G″/G') on the printing outcome was investigated to evaluate the printability of hydrogel-based bioinks.
4D Printing of Robust Hydrogels Consisted of Agarose Nanofibers and Polyacrylamide.
This work opened a new avenue for creating more complex architectures than 3D with excellent properties, which is important in the macromolecule fields for the wide applications.
3D-Printable Bioactivated Nanocellulose-Alginate Hydrogels.
The 3D-printable bioactivated nanocellulose-alginate hydrogel offers a platform for the development of biomedical devices, wearable sensors, and drug-releasing materials.